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Article

Jagged and Delta-like ligands control distinct events during airway progenitor cell differentiation

21 Oct 2019

Abstract excerpt

Notch signaling regulates cell fate selection during development in multiple organs including the lung. Previous studies on the role of Notch in the lung focused mostly on Notch pathway core components or receptor-specific functions. It is unclear, however, how Jagged or Delta-like ligands collectively or individually (Jag1, Jag2, Dll1, Dll4) influence differentiation of airway epithelial progenitors. Using mouse...

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PMID: 31631837
DOI: 10.7554/elife.50487

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