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Article

EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway.

Oxidative medicine and cellular longevity - 1 Jan 2022

Wang Yan, Luo Shiyong, Wang Yuxuan, Yang Shengbang, Huang Zhitong, Zhu Xuejin, Cai Shanghua, Guo Qifeng, Zhong Weide, Liu Sihong

Abstract excerpt

The aim of this study is to elucidate molecular mechanism by which E1A-like inhibitor of differentiation 3 (EID3) promotes cancer stem cell-like phenotypes in osteosarcoma. Overexpression of EID3 in osteosarcoma cells generated more spherical clones, enhanced the expression of stemness-associated genes, and promoted chemoresistance, invasion, and metastasis. Furthermore, osteosarcoma cells overexpressing EID3 had...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 36071872
DOI: 10.1155/2022/5941562
PMCID: PMC9441394

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