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Article

Let-7d miRNA Shows Both Antioncogenic and Oncogenic Functions in Osteosarcoma-Derived 3AB-OS Cancer Stem Cells.

Journal of cellular physiology - 1 Aug 2016

Di Fiore Riccardo, Drago-Ferrante Rosa, Pentimalli Francesca, Di Marzo Domenico, Forte Iris Maria, Carlisi Daniela, De Blasio Anna, Tesoriere Giovanni, Giordano Antonio, Vento Renza

Abstract excerpt

Osteosarcoma (OS), an aggressive highly invasive and metastatic bone-malignancy, shows therapy resistance and recurrence, two features that likely depend on cancer stem cells (CSCs), which hold both self-renewing and malignant potential. So, effective anticancer therapies against OS should specifically target and destroy CSCs. We previously found that the let-7d microRNA was downregulated in the 3AB-OS-CSCs,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26679758
DOI: 10.1002/jcp.25291

Genes

BCL2
CCND2
CXCR4
HMGA2
MMP9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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