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Article

DHFR and MDR1 upregulation is associated with chemoresistance in osteosarcoma stem-like cells

8 May 2017

Abstract excerpt

Tumor-initiating cells (TICs) are defined as a specialized subset of cells with tumor-initiating capacity that can initiate tumor growth, tumor relapse and metastasis. In the present study, osteosarcoma TICs (OS‑TICs) were isolated and enriched from the osteosarcoma U2OS and MG‑63 cell lines using sphere formation assays and serum‑depleted media. These enriched OS-TICs showed the expression of several typical...

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PMID: 28693150
DOI: 10.3892/ol.2017.6132

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