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Clusterin knockdown has effects on intracellular and secreted von Willebrand factor in human umbilical vein endothelial cells

16 Feb 2024

Abstract excerpt

Alterations in von Willebrand factor (VWF) have an important role in human health and disease. Deficiency of VWF is associated with symptoms of bleeding and excesses of VWF are associated with thrombotic outcomes. Understanding the mechanisms that drive VWF regulation can lead to a better understanding of modulation of VWF levels in humans. We identified clusterin (CLU) as a potential candidate regulator of VWF...

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PMID: 38363768
DOI: 10.1371/journal.pone.0298133

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