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Article

Alternative Splicing Role in New Therapies of Spinal Muscular Atrophy

28 Aug 2021

Abstract excerpt

It has been estimated that 80% of the pre-mRNA undergoes alternative splicing, which exponentially increases the flow of biological information in cellular processes and can be an attractive therapeutic target. It is a crucial mechanism to increase genetic diversity. Disturbed alternative splicing is observed in many disorders, including neuromuscular diseases and carcinomas. Spinal Muscular Atrophy (SMA) is an...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34573328
DOI: 10.3390/genes12091346

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