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Article

Familial colorectal cancer: risk factors, screening strategies and personalized medicine.

Cancer genetics - 1 Apr 2026

Maria-Alexia Pungă, Cristina Radu, Andreea-Ramona Treteanu, Octavian Andronic, Viorica Rădoi

Abstract excerpt

Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with approximately 25-30 % of cases exhibiting a familial component driven by germline mutations in DNA mismatch repair genes (Lynch syndrome) or the APC gene (familial adenomatous polyposis). Despite advances in screening and early detection, significant challenges persist in identifying at-risk individuals, optimizing...

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Identifiers

PMID: 41771225
DOI: 10.1016/j.cancergen.2026.02.008

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APC

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