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Article

Inherited predisposition to colorectal cancer: towards a more complete picture.

Journal of medical genetics - 1 Dec 2015

Short Emma, Thomas Laura E, Hurley Joanna, Jose Sian, Sampson Julian R

Abstract excerpt

Colorectal carcinoma (CRC) is the third most common cancer worldwide. Hereditary factors are important in 15%-35% of affected patients. This review provides an update on the genetic basis of inherited predisposition to CRC. Currently known genetic factors include a group of highly penetrant mutant genes associated with rare mendelian cancer syndromes and a group of common low-penetrance alleles that have been...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26297796
DOI: 10.1136/jmedgenet-2015-103298

Genes

NTHL1
POLD1
POLE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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