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Article

Cyclic AMP Mimics the Anti-ageing Effects of Calorie Restriction by Up-Regulating Sirtuin.

Scientific reports - 8 Jul 2015

Wang Zhuoran, Zhang Lu, Liang Yaru, Zhang Chi, Xu Zhiyu, Zhang Lang, Fuji Ryosuke, Mu Wei, Li Liyuan, Jiang Junjun, Ju Yong, Wang Zhao

Abstract excerpt

Cyclic adenosine monophosphate (cAMP) plays an important role in many biological processes as a second messenger, and cAMP treatment has been reported to extend the lifespan of wild-type Drosophila melanogaster. Our study showed that exogenous cAMP improved ageing-related phenotypes by increasing the protein level of Sirtuins, which prevented metabolic disorders to mimic the effect of calorie restriction....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26153625
DOI: 10.1038/srep12012
PMCID: PMC4648391

Genes

SIRT1
SIRT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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