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Pseudomonas aeruginosa Quorum Sensing Molecule Alters Skeletal Muscle Protein Homeostasis by Perturbing the Antioxidant Defense System

30 Sept 2019

Abstract excerpt

Pseudomonas aeruginosa , a bacterium that is resistant to treatment, causes serious acute, persistent, and relapsing infections in humans. There is increasing evidence that bacterial excreted small molecules play a critical role during infection. We have shown that a quorum sensing (QS)-regulated excreted small molecule, 2-AA, which is abundantly produced by P. aeruginosa , promotes persistent infections, dampens...

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PMID: 31575771
DOI: 10.1128/mbio.02211-19

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