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Skeletal Muscle Mitochondrial Dysfunction Mediated by <i>Pseudomonas aeruginosa</i> Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds

2024-05-05

Abstract excerpt

<h4>ABSTRACT</h4> Sepsis and chronic infections with Pseudomonas aeruginosa, a leading “ESKAPE” bacterial pathogen, are associated with increased morbidity and mortality and skeletal muscle atrophy. The actions of this pathogen on skeletal muscle remain poorly understood. In skeletal muscle, mitochondria serve as a crucial energy source, which may be perturbed by infection. Here, using the well-established backb...

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Literature Corpus work
c741ba96-c9a6-5783-b185-424dfac3aaef
DOI
10.1101/2024.05.03.592480
Open publication

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Skeletal Muscle Mitochondrial Dysfunction Mediated by <i>Pseudomonas aeruginosa</i> Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted CompoundsDOI 10.1101/2024.05.03.592480
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