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NK Cell Precursors in Human Bone Marrow in Health and Inflammation

28 Aug 2019

Abstract excerpt

Similar to other blood cells, NK cells are generated from hematopoietic stem cells (HSC) residing in the bone marrow (BM). The BM harbors multipotent Lin-CD34+CD45RA+CD10+CD38+ common lymphoid progenitors (CLP) generating in vitro T, B, NK and Dendritic Cells that are devoid of erythroid, myeloid, and megakaryocytic potential. In addition, CD7 coexpression on CD34+CD45RA+ HSCs also enriches for NK cell...

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PMID: 31555276
DOI: 10.3389/fimmu.2019.02045

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