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The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity.

Biochimica et biophysica acta - 1 Aug 2015

Rinaldi Débora E, Corradi Gerardo R, Cuesta Lucía Martínez, Adamo Hugo P, de Tezanos Pinto Felicitas

Abstract excerpt

P-type ion pumps are membrane transporters that have been classified into five subfamilies termed P1-P5. The ion transported by the P5-ATPases is not known. Five genes named ATP13A1-ATP13A5 that belong to the P5-ATPase group are present in humans. Loss-of-function mutations in the ATP13A2 gene (PARK9, OMIM 610513) underlay a form of Parkinson's disease (PD) known as the Kufor-Rakeb syndrome (KRS), which belongs...

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PMID: 25912790
DOI: 10.1016/j.bbamem.2015.04.008

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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