Article
The role of clonal interference in the evolutionary dynamics of plasmid-host adaptation.
mBio - 1 Jan 2012
Hughes Julie M, Lohman Brian K, Deckert Gail E, Nichols Eric P, Settles Matt, Abdo Zaid, Top Eva M
Abstract excerpt
UNLABELLED: Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the medical relevance, little is known about the evolutionary dynamics through which drug resistance plasmids adapt to new hosts and thereby persist in the absence of antibiotics. We previously showed that the...
Topics
- Adaptation, Physiological
- Bacterial Proteins
- Clonal Evolution
- DNA Helicases
- Evolution, Molecular
- Mutation
- Plasmids
- Shewanella
- Trans-Activators