Article
The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.
Nucleic acids research - 1 Oct 2009
Al-Minawi Ali Z, Lee Yin-Fai, Håkansson Daniel, Johansson Fredrik, Lundin Cecilia, Saleh-Gohari Nasrollah, Schultz Niklas, Jenssen Dag, Bryant Helen E, Meuth Mark, Hinz John M, Helleday Thomas
Abstract excerpt
Both the ERCC1-XPF complex and the proteins involved in homoIogous recombination (HR) have critical roles in inter-strand cross-link (ICL) repair. Here, we report that mitomycin C-induced lesions inhibit replication fork elongation. Furthermore, mitomycin C-induced DNA double-strand breaks (DSBs) are the result of the collapse of ICL-stalled replication forks. These are not formed through replication run off, as...
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