Identification and Confirmation of Potentially Actionable Germline Mutations in Tumor-Only Genomic Sequencing

Abstract excerpt

PURPOSE Tumor-only genomic profiling (TGP) is increasingly advocated for all patients with cancer given the possible therapeutic implications. It is critical to develop clinical algorithms to identify and address potentially actionable germline findings identified by TGP. METHODS A multidisciplinary team analyzed publicly available data for genes in which mutations are implicated in germline cancer susceptibility...

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