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Prevalence of Potentially Pathogenic Germline Variants Among Adult Patients in the Philippines With Solid Malignancies Who Underwent Tumor Genomic Profiling.

JCO global oncology - 1 Jun 2024

Franco Paula Isabel, Andal Jose Jasper, Ang Daphne Chua, Que Frances Victoria

Abstract excerpt

PURPOSE: In high-income countries, 2%-10% of tumor genomic profiling (TGP) reports reveal incidental pathogenic germline variants. A third of these patients would not qualify for genetic testing on the basis of current guidelines. Our study determined the prevalence of potentially pathogenic germline variants (PPGVs) in TGP results of adult patients with solid malignancies in the Philippines. METHODS: Annotated...

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Source

Identifiers

PMID: 38843470
DOI: 10.1200/GO.24.00019

Genes

HP
APC
BRCA1
BRCA2
CDH1
CDKN2A
EGFR
MLH1
MSH2
MSH6
PTEN
RAD51C
RAD51D
SMAD4

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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