Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Germline-focused analysis of tumour-detected variants in 49,264 cancer patients: ESMO Precision Medicine Working Group recommendations.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Mar 2023

Kuzbari Z, Bandlamudi C, Loveday C, Garrett A, Mehine M, George A, Hanson H, Snape K, Kulkarni A, Allen S, Jezdic S, Ferrandino R, Westphalen C B, Castro E, Rodon J, Mateo J, Burghel G J, Berger M F, Mandelker D, Turnbull C

Abstract excerpt

BACKGROUND: The European Society for Medical Oncology Precision Medicine Working Group (ESMO PMWG) was reconvened to update its 2018/19 recommendations on follow-up of putative germline variants detected on tumour-only sequencing, which were based on an analysis of 17 152 cancers. METHODS: We analysed an expanded dataset including 49 264 paired tumour-normal samples. We applied filters to tumour-detected variants...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Frequency
Share to Genes, BRCA2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Germ-Line Mutation

Share to Neoplasms

Share to Precision Medicine

Source

Identifiers

PMID: 36529447
DOI: 10.1016/j.annonc.2022.12.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Germline-focused analysis of tumour-detected variants in 49,264 cancer patients: ESMO Precision Medicine Working Group recommendations.PMID 36529447Read ↗

Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working GroupSemantic proximity Read ↗

Prevalence and Distribution of Unexpected Actionable Germline Pathogenic Variants Identified on Broad-Based Multigene Panel Testing Among Patients With Cancer.Semantic proximity Read ↗

Germline testing data validate inferences of mutational status for variants detected from tumor-only sequencingSemantic proximity Read ↗

Germline Findings in Tumor-Only Sequencing: Points to Consider for Clinicians and Laboratories.Semantic proximity Read ↗

Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profilingSemantic proximity Read ↗

Assessing actionability and incidental findings of germline variants in two precision oncology trials.Semantic proximity Read ↗

Precision medicine in heritable cancer: when somatic tumour testing and germline mutations meetSemantic proximity Read ↗

Prevalence of Potentially Pathogenic Germline Variants Among Adult Patients in the Philippines With Solid Malignancies Who Underwent Tumor Genomic Profiling.Semantic proximity Read ↗

Identification and Management of Pathogenic Variants in BRCA1, BRCA2, and PALB2 in a Tumor-Only Genomic Testing Program.Semantic proximity Read ↗

Germline pathogenic variants identification through Comprehensive Cancer Genome ProfilingSemantic proximity Read ↗

Pathogenic Germline Variants in 10,389 Adult Cancers.Semantic proximity Read ↗

Prevalence of Pathogenic Germline Variants in Cancer Susceptibility Genes using the All of Us DatasetSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.