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Article

Loss of αklotho causes reduced motor ability and short lifespan in zebrafish

23 Jul 2021

Abstract excerpt

The klotho gene encodes a transmembrane protein αKlotho that interacts with a fibroblast growth factor (FGF) receptor in renal tubular epithelial cells and functions as a co-receptor for FGF23, which is an osteocytes-derived hormone. This bone-to-kidney signal promotes urinary phosphate excretion. Interestingly, αKlotho knockout mice show an accelerated aging and a shortened life span. Similarly, C. elegans...

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PMID: 34301962
DOI: 10.1038/s41598-021-93909-y

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