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Article

Acquired mechanisms of immune escape in cancer following immunotherapy

22 Nov 2018

Abstract excerpt

Immunotherapy has revolutionized the management of numerous cancers; however, a substantial proportion that initially respond subsequently acquire means of immune escape and relapse. Analysis of recent clinical trials permits us to preliminarily understand how immunotherapies exert evolutionary pressures: selecting cancer subclones deficient in antigenicity and/or immunogenicity, thereby facilitating immune escape.

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PMID: 30466478
DOI: 10.1186/s13073-018-0598-2

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