MHC Class I Deficiency in Solid Tumors and Therapeutic Strategies to Overcome It.

Abstract excerpt

It is now well accepted that the immune system can control cancer growth. However, tumors escape immune-mediated control through multiple mechanisms and the downregulation or loss of major histocompatibility class (MHC)-I molecules is a common immune escape mechanism in many cancers. MHC-I molecules present antigenic peptides to cytotoxic T cells, and MHC-I loss can render tumor cells invisible to the immune...

Topics

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• Antigens, Neoplasm
• CD4-Positive T-Lymphocytes
• Down-Regulation
• Histocompatibility Antigens Class I
• Immunotherapy