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Article

Molecular determinants for enzalutamide-induced transcription in prostate cancer

5 Sept 2019

Abstract excerpt

Enzalutamide, a second-generation androgen receptor (AR) antagonist, has demonstrated clinical benefit in men with prostate cancer. However, it only provides a temporary response and modest increase in survival, indicating a rapid evolution of resistance. Previous studies suggest that enzalutamide may function as a partial transcriptional agonist, but the underlying mechanisms for enzalutamide-induced...

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PMID: 31501863
DOI: 10.1093/nar/gkz790

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