Article

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistance

2018-10-02

Abstract excerpt

Genomic amplification of the androgen receptor (AR) is an established mechanism of antiandrogen resistance in prostate cancer. Here we show that the magnitude of AR signaling output, independent of AR genomic alteration or expression level, also contributes to antiandrogen resistance, through upregulation of the coactivator GREB1. We demonstrate 100-fold heterogeneity in AR output within cell lines and show that c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c99eed22-2c45-556b-aa68-532fdff00264
DOI: 10.1101/433755

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GREB1 amplifies androgen receptor output in prostate cancer and contributes to antiandrogen resistanceDOI 10.1101/433755Read

GREB1 amplifies androgen receptor output in human prostate cancer and contributes to antiandrogen resistanceSemantic proximity Read

Androgen receptor signaling regulates the transcriptome of prostate cancer cells by modulating global alternative splicingSemantic proximity Read

Androgen Receptor Signaling Regulates the Transcriptome of Prostate Cancer Cells by Modulating Global Alternative SplicingSemantic proximity Read

Supraphysiological Androgens Promote the Tumor Suppressive Activity of the Androgen Receptor through cMYC Repression and Recruitment of the DREAM ComplexSemantic proximity Read

CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate CancerSemantic proximity Read

EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cellsSemantic proximity Read

Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancerSemantic proximity Read

Durable Response of Enzalutamide-resistant Prostate Cancer to Supraphysiological Testosterone Is Associated with a Multifaceted Growth Suppression and Impaired DNA Damage Response Transcriptomic Program in Patient-derived XenograftsSemantic proximity Read

Linking prostate cancer cell AR heterogeneity to distinct castration and enzalutamide responsesSemantic proximity Read

TALEN-engineered AR gene rearrangements reveal endocrine uncoupling of androgen receptor in prostate cancerSemantic proximity Read

Increased AR expression in castration-resistant prostate cancer rapidly induces AR signaling reprogramming with the collaboration of EZH2Semantic proximity Read

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapiesSemantic proximity Read