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Article

GATA2 facilitates steroid receptor coactivator recruitment to the androgen receptor complex

8 Dec 2014

Abstract excerpt

The androgen receptor (AR) is a key driver of prostate cancer (PC), even in the state of castration-resistant PC (CRPC) and frequently even after treatment with second-line hormonal therapies such as abiraterone and enzalutamide. The persistence of AR activity via both ligand-dependent and ligand-independent mechanisms (including constitutively active AR splice variants) highlights the unmet need for alternative...

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PMID: 25489091
DOI: 10.1073/pnas.1421415111

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