Article
Glucose-6-Phosphate Dehydrogenase Deficiency.
Hematology/oncology clinics of North America - 1 Apr 2016
Luzzatto Lucio, Nannelli Caterina, Notaro Rosario
Abstract excerpt
G6PD is a housekeeping gene expressed in all cells. Glucose-6-phosphate dehydrogenase (G6PD) is part of the pentose phosphate pathway, and its main physiologic role is to provide NADPH. G6PD deficiency, one of the commonest inherited enzyme abnormalities in humans, arises through one of many possible mutations, most of which reduce the stability of the enzyme and its level as red cells age. G6PD-deficient persons...
Topics
- Alleles
- Animals
- Comorbidity
- Disease Management
- Disease Models, Animal
- Drug Discovery
- Global Health
- Glucosephosphate Dehydrogenase
- Glucosephosphate Dehydrogenase Deficiency
- Humans
- Mutation