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Article

FliC's Hypervariable D3 Domain Is Required for Robust Anti-Flagellin Primary Antibody Responses.

ImmunoHorizons - 5 Sept 2019

López-Yglesias Américo H, Lu Chun-Chi, Zhao Xiaodan, Chou Tiffany, VandenBos Tim, Strong Roland K, Smith Kelly D

Abstract excerpt

Bacterial flagellin is a well-known agonist of the innate immune system that induces proinflammatory responses through the TLR5 and Naip5/6 recognition pathways. Several clinical trials investigating flagellin fusion proteins have demonstrated promising results for inducing protective immunity toward influenza virus, which has been largely attributed to flagellin's ability to activate TLR5. Our laboratory...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31488506
DOI: 10.4049/immunohorizons.1800061
PMCID: PMC11650696

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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