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Article

Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jul 2007

Saha Sukumar, Takeshita Fumihiko, Matsuda Tomoko, Jounai Nao, Kobiyama Kouji, Matsumoto Tetsuya, Sasaki Shin, Yoshida Atsushi, Xin Ke-Qin, Klinman Dennis M, Uematsu Satoshi, Ishii Ken J, Akira Shizuo, Okuda Kenji

Abstract excerpt

Flagellin is a key component of the flagella of many pathogens, including Pseudomonas aeruginosa. Flagellin is an attractive vaccine candidate because it is readily produced and manipulated as a recombinant protein and has intrinsic adjuvant activity mediated through TLR5. Although DNA vaccines encoding native Pseudomonas B-type (FliC) or A-type (FlaA) flagellin are strongly immunogenic, the resultant Ab response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17617608
DOI: 10.4049/jimmunol.179.2.1147

Genes

TLR5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Blocking of the TLR5 activation domain hampers protective potential of flagellin DNA vaccine.PMID 17617608Read ↗

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