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Article

Intra- and inter-biosynthetic gene cluster allelic variation as drivers of chemical diversification in Streptomyces.

Essays in biochemistry - 19 Aug 2026

Nayeb G Hosseini Golsa, Barona-Gómez Francisco

Abstract excerpt

In this essay, we postulate that biosynthetic gene clusters (BGCs) chemical diversity arises in Streptomyces cultures from allelic variation both within a single BGC-intra-BGC, and across homologous BGCs-inter-BGC. These layers of genetic diversification reshape pathway architecture, modulate catalytic efficiency, and redefine substrate channeling, ultimately expanding the repertoire of specialized metabolites...

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Identifiers

PMID: 42388094
DOI: 10.1042/EBC20250013
PMCID: PMC13500780

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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