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Tumor cell‐expressed SerpinB2 is present on microparticles and inhibits metastasis

19 Mar 2014

Abstract excerpt

Expression of SerpinB2 (plasminogen activator inhibitor type 2/PAI-2) by certain cancers is associated with a favorable prognosis. Although tumor-associated host tissues can express SerpinB2, no significant differences in the growth of a panel of different tumors in SerpinB2(-/-) and SerpinB2(+/+) mice were observed. SerpinB2 expression by cancer cells (via lentiviral transduction) also had no significant effect...

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PMID: 24644264
DOI: 10.1002/cam4.229

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