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Article

Identification of predictive genetic signatures of Cytarabine responsiveness using a 3D acute myeloid leukaemia model

26 Aug 2019

Abstract excerpt

This study reports the establishment of a bone marrow mononuclear cell (BMMC) 3D culture model and the application of this model to define sensitivity and resistance biomarkers of acute myeloid leukaemia (AML) patient bone marrow samples in response to Cytarabine (Ara-C) treatment. By mimicking physiological bone marrow microenvironment, the growth conditions were optimized by using frozen BMMCs derived from...

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PMID: 31449347
DOI: 10.1111/jcmm.14608

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