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Article

Microenvironment matters: In vitro 3D bone marrow niches differentially modulate survival, phenotype and drug responses of acute myeloid leukemia (AML) cells.

Biomaterials - 1 Jan 2025

Cheung Hoi Lam, Wong Yu Hin, Li Yuk Yin, Yang Xingxing, Ko Lok Him, Tan Kabigting Jessica Evangeline, Chan Koon Chuen, Leung Anskar Yu Hung, Chan Barbara Pui

Abstract excerpt

Acute myeloid leukemia (AML) is a deadly form of leukemia with ineffective traditional treatment and frequent chemoresistance-associated relapse. Personalized drug screening holds promise in identifying optimal regimen, nevertheless, primary AML cells undergo spontaneous apoptosis during cultures, invalidating the drug screening results. Here, we reconstitute a 3D osteogenic niche (3DON) mimicking that in bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39088912
DOI: 10.1016/j.biomaterials.2024.122719

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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