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Article

Primary Aldosteronism

26 Aug 2019

Abstract excerpt

Aldosterone-producing adenomas with somatic mutations in the KCNJ5 G-protein–coupled inwardly rectifying potassium channel are a cause of primary aldosteronism. These mutations drive aldosterone excess, but their role in cell growth is undefined. Our objective was to determine the role of KCNJ5 mutations in adrenal cell proliferation and apoptosis. The Ki67 proliferative index was positively correlated with...

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Share to Adrenal and Paraganglionic Tumors
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PMID: 31446799
DOI: 10.1161/hypertensionaha.119.13476

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