Article
Primary Aldosteronism: Small Molecule Antagonists of Mutant KCNJ5 Potassium Channels.
Hypertension (Dallas, Tex. : 1979) - 1 May 2026
Mir-Bashiri Sanas, Tetti Martina, Fröbel Dennis, Pang Yingxian, Yang Yuhong, Reiss Dunja, Bibus Jonas, Peitzsch Mirko, Eisenhofer Graeme, Bechmann Nicole, Reincke Martin, Williams Tracy Ann
Abstract excerpt
BACKGROUND: Mutations in the KCNJ5 (potassium inwardly rectifying channel subfamily J member 5) gene, encoding an inwardly rectifying potassium channel, can drive aldosterone overproduction in a subset of aldosterone-producing adenomas and in familial hyperaldosteronism type III. Our objective was to identify small molecule compounds that specifically antagonize mutant KCNJ5 channels. METHODS: Virtual screening...
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