Article
Aldosterone-Producing Adenomas: Histopathology-Genotype Correlation and Identification of a Novel CACNA1D Mutation.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2017
Tan Geok Chin, Negro Giulia, Pinggera Alexandra, Tizen Laim Nur Maya Sabrina, Mohamed Rose Isa, Ceral Jiri, Ryska Ales, Chin Long Kha, Kamaruddin Nor Azmi, Mohd Mokhtar Norfilza, A Jamal A Rahman, Sukor Norlela, Solar Miroslav, Striessnig Joerg, Brown Morris Jonathan, Azizan Elena Aisha
Abstract excerpt
Mutations in KCNJ5, ATP1A1, ATP2B3, CACNA1D, and CTNNB1 are thought to cause the excessive autonomous aldosterone secretion of aldosterone-producing adenomas (APAs). The histopathology of KCNJ5 mutant APAs, the most common and largest, has been thoroughly investigated and shown to have a zona fasciculata-like composition. This study aims to characterize the histopathologic spectrum of the other genotypes and...
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