Article
The preleukemic TCF3-PBX1 gene fusion can be generated in utero and is present in ≈0.6% of healthy newborns
21 Aug 2019
Abstract excerpt
] This requirement partially explains the long latency of these leukemias, which emerge after birth at age 2 to 5 years (range, 1-15 years). Rarer B-ALL subtypes, characterized by KMT2A (MLL) translocations, are also generated in utero as evidenced by similar studies.
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