Article
PPARdelta is a very low-density lipoprotein sensor in macrophages.
Proceedings of the National Academy of Sciences of the United States of America - 4 Feb 2003
Chawla Ajay, Lee Chih-Hao, Barak Yaacov, He Weimin, Rosenfeld John, Liao Debbie, Han Jungyeob, Kang Heonjoong, Evans Ronald M
Abstract excerpt
Although triglyceride-rich particles, such as very low-density lipoprotein (VLDL), contribute significantly to human atherogenesis, the molecular basis for lipoprotein-driven pathogenicity is poorly understood. We demonstrate that in macrophages, VLDL functions as a transcriptional regulator via the activation of the nuclear receptor peroxisome proliferator-activated receptor delta. The signaling components of...
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