Article
Lipid homeostasis and inflammatory activation are disturbed in classically activated macrophages with peroxisomal β-oxidation deficiency.
Immunology - 1 Mar 2018
Geric Ivana, Tyurina Yulia Y, Krysko Olga, Krysko Dmitri V, De Schryver Evelyn, Kagan Valerian E, Van Veldhoven Paul P, Baes Myriam, Verheijden Simon
Abstract excerpt
Macrophage activation is characterized by pronounced metabolic adaptation. Classically activated macrophages show decreased rates of mitochondrial fatty acid oxidation and oxidative phosphorylation and acquire a glycolytic state together with their pro-inflammatory phenotype. In contrast, alternatively activated macrophages require oxidative phosphorylation and mitochondrial fatty acid oxidation for their...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.