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Article

The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines

1 Aug 2019

Abstract excerpt

PURPOSE: Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a tetramethylfolate dehydrogenase enzyme involved in folate metabolism. The aim of this study is to determine the effect of MTHFD2 on the proliferation and metastasis of colorectal cancer (CRC). PATIENTS AND METHODS: MTHFD2 was silenced or overexpressed in CRC cells. qRT-PCR and Western blotting were used to analyze mRNA and protein expression,...

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PMID: 31496738
DOI: 10.2147/ott.s210800

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