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Article

The importance of mitochondrial folate enzymes in human colorectal cancer

22 Nov 2016

Abstract excerpt

Folate plays a pivotal role in the one-carbon metabolism needed for methylation reactions, nucleotide synthesis, and DNA repair. Although folate metabolism was recently shown to be associated with carcinogenesis in some solid tumors, the importance of folate metabolism in colorectal cancer remains unclear. In the present investigation we found that expression of three mitochondrial folate metabolic enzymes,...

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Identifiers

PMID: 27878282
DOI: 10.3892/or.2016.5264

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