Fragile X mental retardation protein protects against tumour necrosis factor-mediated cell death and liver injury

Abstract excerpt

Objective The Fragile X mental retardation (FMR) syndrome is a frequently inherited intellectual disability caused by decreased or absent expression of the FMR protein (FMRP). Lack of FMRP is associated with neuronal degradation and cognitive dysfunction but its role outside the central nervous system is insufficiently studied. Here, we identify a role of FMRP in liver disease. Design Mice lacking Fmr1 gene...

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