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Elevated progranulin contributes to synaptic and learning deficit due to loss of fragile X mental retardation protein

23 Sept 2017

Abstract excerpt

Fragile X syndrome is an inheritable form of intellectual disability caused by loss of fragile X mental retardation protein (FMRP, encoded by the FMR1 gene). Absence of FMRP caused overexpression of progranulin (PGRN, encoded by GRN), a putative tumour necrosis factor receptor ligand. In the present study, we found that progranulin mRNA and protein were upregulated in the medial prefrontal cortex of Fmr1...

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PMID: 29096020
DOI: 10.1093/brain/awx265

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