Article
A rare DNA contact mutation in cancer confers p53 gain-of-function and tumor cell survival via TNFAIP8 induction.
Molecular oncology - 1 Oct 2016
Monteith Jessica A, Mellert Hestia, Sammons Morgan A, Kuswanto Laudita A, Sykes Stephen M, Resnick-Silverman Lois, Manfredi James J, Berger Shelley L, McMahon Steven B
Abstract excerpt
The p53 tumor suppressor gene encodes a sequence-specific transcription factor. Mutations in the coding sequence of p53 occur frequently in human cancer and often result in single amino acid substitutions (missense mutations) in the DNA binding domain (DBD), blocking normal tumor suppressive functions. In addition to the loss of canonical functions, some missense mutations in p53 confer gain-of-function (GOF)...
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