Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectors

31 Jul 2019

Abstract excerpt

system to investigate cholangiocyte-to-hepatocyte differentiation. However, as current gene manipulation methods require organoid dissociation into single cells and have only low efficiency, it is difficult to dissect specific gene functions in these organoids. Here we developed the adeno-associated virus (AAV) vector AAV-DJ as a powerful tool to transduce mouse and human liver ductal organoids. Via...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Liver physiology and pathology
Share to Organ Transplantation Techniques and Outcomes
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31366731
DOI: 10.1074/jbc.ra119.008616

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene manipulation in liver ductal organoids by optimized recombinant adeno-associated virus vectorsPMID 31366731Read ↗

A Human Multi-Lineage Hepatic Organoid Model for Liver FibrosisSemantic proximity Read ↗

A human multi-lineage hepatic organoid model for liver fibrosis.Semantic proximity Read ↗

Long-Term Correction of Diabetes in Mice by In Vivo Reprogramming of Pancreatic DuctsSemantic proximity Read ↗

Integrative omics analysis reveals gene regulatory mechanisms distinguishing organoid-derived hepatocytes from primary human hepatocytesSemantic proximity Read ↗

Gene Regulatory Network Analysis and Engineering Directs Development and Vascularization of Multilineage Human Liver OrganoidsSemantic proximity Read ↗

Orthogonal CRISPR screens and human liver chimeric mice identify hepatitis B virus host factorsSemantic proximity Read ↗

Adeno-associated Virus-mediated Silencing of Sox4 Leads to Long-Term Amelioration of Liver Phenotypes in Mouse Models of Alagille Syndrome.Semantic proximity Read ↗

Chemical Cocktails Enable Hepatic Reprogramming of Mouse Fibroblasts with a Single Transcription FactorSemantic proximity Read ↗

Single-Cell Transcriptome Analysis of Mouse Liver Cell-Specific Tropism and Transcriptional Dysregulation Following Intravenous Administration of AAVrh.10 VectorsSemantic proximity Read ↗

Eye lens organoids going simple: characterization of a new 3-dimensional organoid model for lens development and pathologySemantic proximity Read ↗

Kras-driven heterotopic tumor development from hepatobiliary organoidsSemantic proximity Read ↗

Generation of functional hepatocytes by forward programming with nuclear receptorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.