Nuclear KIT induces a NFKBIB-RELA-KIT autoregulatory loop in imatinib-resistant gastrointestinal stromal tumors

Abstract excerpt

Gastrointestinal stromal tumors (GISTs) are frequently driven by auto-activated, mutant KIT and have durable response to KIT tyrosine kinase inhibitor. However, acquired resistance is an increasing clinical issue in GIST patients receiving front-line imatinib therapy. Our previous studies showed the colocalization of KIT with DAPI-stained nuclei in GIST cells without knowing the role of nuclear KIT in GIST...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Gastrointestinal disorders and treatments
• Share to Gastrointestinal Tumor Research and Treatment
• Share to Sarcoma Diagnosis and Treatment