Article
RAF1 facilitates KIT signaling and serves as a potential treatment target for gastrointestinal stromal tumor.
Oncogene - 1 Jun 2024
Zhang Liangying, Zhang Shaoting, Cao Xu, Shi Jun, Zhao Sien, Tian Jinhai, Xiao Kun, Wang Ming, Liu Jing, Wang Chengdong, Zhou Liangji, Yu Yuanyuan, Zhao Hui, Li Shujing, Sun Jianmin
Abstract excerpt
The aberrant activation of RAS/RAF/MEK/ERK signaling is important for KIT mutation-mediated tumorigenesis of gastrointestinal stromal tumor (GIST). In this study, we found that inhibition of RAF1 suppresses the activation of both wild-type KIT and primary KIT mutations in GIST, with primary KIT mutations showing greater sensitivity. This suggests a positive feedback loop between KIT and RAF1, wherein RAF1...
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