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Article

Genetic determinants of VWF clearance and FVIII binding modify FVIII pharmacokinetics in pediatric hemophilia A patients.

Blood - 12 Sept 2019

Swystun Laura L, Ogiwara Kenichi, Rawley Orla, Brown Christine, Georgescu Ilinca, Hopman Wilma, Labarque Veerle, Male Christoph, Thom Katharina, Blanchette Victor S, Carcao Manuel D, Lillicrap David

Abstract excerpt

Factor VIII (FVIII) pharmacokinetic (PK) properties show high interpatient variability in hemophilia A patients. Although previous studies have determined that age, body mass index, von Willebrand factor antigen (VWF:Ag) levels, and ABO blood group status can influence FVIII PK, they do not account for all observed variability. In this study, we aim to describe the genetic determinants that modify the FVIII PK...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 31350267
DOI: 10.1182/blood.2019000190
PMCID: PMC13127298

Genes

VWF
ABO
CLEC4M
STAB2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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