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Article

Severe congenital protein C deficiency: description of a new mutation and prophylactic protein C therapy and in vivo pharmacokinetics.

Journal of pediatric hematology/oncology - 1 Feb 2008

Tcheng Wendy Y, Dovat Sinisa, Gurel Zafer, Donkin Jennifer, Wong Wing-Yen

Abstract excerpt

Severe congenital protein C deficiency is a rare life-threatening disorder that presents with purpura fulminans, disseminated intravascular coagulation, and thrombotic complications during the neonatal period. Affected children require acute replacement therapy with fresh frozen plasma or protein C concentrate, for example, Ceprotin (Baxter AG, Vienna). Long-term management and outcome is dependent on effective...

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Identifiers

PMID: 18376272
DOI: 10.1097/MPH.0b013e31815d8943

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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