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Article

Common Genetic Variants in ABO and CLEC4M Modulate the Pharmacokinetics of Recombinant FVIII in Severe Hemophilia A Patients.

Thrombosis and haemostasis - 1 Oct 2020

Garcia-Martínez Iris, Borràs Nina, Martorell Marta, Parra Rafael, Altisent Carme, Ramírez Lorena, Álvarez-Román Maria Teresa, Nuñez Ramiro, Megias-Vericat Juan Eduardo, Corrales Irene, Alonso Sofia, Vidal Francisco

Abstract excerpt

The pharmacokinetic (PK) response of severe hemophilia A (HA) patients to infused factor VIII (FVIII) shows substantial variability. Several environmental and genetic factors are associated with changes in FVIII plasma levels and infused FVIII PK. Based on the hypothesis that factors influencing endogenous FVIII can affect FVIII PK, the contribution of single-nucleotide variants (SNVs) in candidate genes was...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32726853
DOI: 10.1055/s-0040-1714214

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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