Article
Genome-wide studies of von Willebrand factor propeptide identify loci contributing to variation in propeptide levels and von Willebrand factor clearance.
Journal of thrombosis and haemostasis : JTH - 1 Sept 2016
Ozel A B, McGee B, Siemieniak D, Jacobi P M, Haberichter S L, Brody L C, Mills J L, Molloy A M, Ginsburg D, Li J Z, Desch K C
Abstract excerpt
UNLABELLED: Essentials Variants at ABO, von Willebrand Factor (VWF) and 2q12 contribute to the variation in plasma in VWF. We performed a genome-wide association study of plasma VWF propeptide in 3,238 individuals. ABO, VWF and 2q12 loci had weak or no association or linkage with plasma VWFpp levels. VWF associated variants at ABO, VWF and 2q12 loci primarily affect VWF clearance rates. SUMMARY: Background...
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