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Article

Biological mechanisms underlying inter‐individual variation in factor VIII clearance in haemophilia

28 Jun 2020

Abstract excerpt

Previous studies have highlighted marked inter-individual variations in factor VIII (FVIII) clearance between patients with haemophilia (PWH). The half-life of infused FVIII has been reported to vary from as little as 5.3 hours in some adult PWH, up to as long as 28.8 hours in other individuals. These differences in clearance kinetics have been consistently observed using a number of different plasma-derived and...

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PMID: 32596930
DOI: 10.1111/hae.14078

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